You are here: Home

Welcome by Dr Janine Erler

Introduction to the Hypoxia and Metastasis Team by Group Leader Janine Erler

The Erler Lab is a cancer biology research group interested in elucidating the underlying processes contributing to tumour progression and patient treatment failure.

All solid tumours over 1cm3 contain regions of hypoxia due inadequate blood supply from insufficient and disorganised vasculature. Tumour hypoxia is clinically associated with poor patient outcome. Hypoxic tumour cells are highly aggressive, metastatic and resistant to therapy, through relatively undefined mechanisms. Understanding how tumours acquire the ability to invade and metastasise is critical for the identification of new targets and development of therapies against metastatic disease.